Labeling Stem Cells with Ferumoxytol, an FDA-Approved Iron Oxide Nanoparticle
نویسندگان
چکیده
منابع مشابه
Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells.
The use of nanometer-sized iron oxide particles combined with molecular imaging techniques enables dynamic studies of homing and trafficking of human hematopoietic stem cells (HSC). Identifying clinically applicable strategies for loading nanoparticles into primitive HSC requires strictly defined culture conditions to maintain viability without inducing terminal differentiation. In the current ...
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Introduction: IIron oxide nanoparticles (IO NP) have an increasing number of biomedical applications. To date, the potential cytotoxicity of these particles remains an issue of debate. Little is known about the cellular interaction or toxic effects of IO NP on differentiation of stem cells. The aim of the present study was to investigate the possible toxic role of different doses of IO NP in di...
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rMSCs; and (b) labeled rMSCs. GAG stains red, nuclei black, and the cytoplasm green. Labeled cells show positive GAG staining (arrows), as well as extracellular iron; (c) results of GAG assay show no significant difference between labeled and unlabeled cells. (scale bar = 20 μm) Iron Oxide Labeling of Mesenchymal Stem Cells with Micrometer-sized Particles: Applications to Cartilage Tissue Engin...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2011
ISSN: 1940-087X
DOI: 10.3791/3482